Guilluy Lab

Exploring Nuclear dynamics in Physiology and Diseases.

Our lab combines interdisciplinary approaches to investigate how nuclear structure and dynamics control cellular processes, such as cell growth and division. Recent projects include:

The nuclear envelope and the control of cell growth

How cells adjust to the spatial and mechanical properties of their environment is a central mechanism in cell biology, under physiological conditions and diseases. Our research aims to identify nuclear mechanisms that control cell growth in response to mechanical constraints of the cellular microenvironment.

Exploring the nucleus of Hydra

Our lab investigates how the nuclear structure of Hydra vulgaris contributes to its unique regeneration potential.

Chromatin-associated proteome

We combine biochemical, genetics and imaging approaches to understand how the proteins associated with chromatin regulate nuclear dynamics and genome stability in physiology and aging.