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Exploring Nuclear dynamics in Physiology and Disease.
Our lab combines interdisciplinary approaches to investigate how nuclear structure and dynamics control cellular processes, such as cell growth and division. Recent projects include:
The nuclear envelope and the control of cell growth
How cells adjust to the spatial and mechanical properties of their environment is a central mechanism in cell biology, under both physiological and pathological conditions. Our research aims to identify nuclear mechanisms that control cell growth in response to mechanical constraints of the cellular microenvironment.
Exploring the nucleus of Hydra
Our lab investigates how the nuclear structure of Hydra vulgaris contributes to its unique regeneration potential.
Chromatin-associated proteome
We combine biochemical, genetic and imaging approaches to understand how the proteins associated with chromatin regulate nuclear dynamics and genome stability in physiology and aging.