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    Guilluy Lab

    Publications

    Guilluy Lab

    Publications

    Nuclear SUN1 stabilizes endothelial cell junctions via microtubules to regulate blood vessel formation . Buglak D.B., Bougaran P., Kulikauskas M.R., Liu Z., Monaghan-Benson E., Gold A.L., Marvin A.P., Burciu A., Tanke N.T., Oatley M., Shea N., Ricketts S., Kinghorn K., Johnson B. N., Shiau C.E., Rogers S., Guilluy C. and Bautch V.L. ELife Mar 29, 2023

    SUN2 regulates mitotic duration in response to extracellular matrix rigidity. . Belaadi N., Pernet .L, Aureille J., Chadeuf G., Rio M., Vaillant N., Vitiello E., Lafanechère L., Loirand G. and Guilluy C. PNAS 2022 Nov 8;119(45):e2116167119.

    Direction of epithelial folding defines impact of mechanical forces on epithelial state. . S. Blonski, J. Aureille, S. Badawi, D. Zaremba, L. Pernet, A. Grichine, S. Fraboulet, P.M. Korczyk, P. Recho, C. Guilluy, and M. E. Dolega. Dev. Cell. 2021. Volume 56, Issue 23, 6 December 2021, Pages 3222-3234.e6.

    Cell fluorescence photo-activation as a method to select and study cellular sub populations grown in mechanically heterogeneous environments. . J. Aureille, M. Pezet, L. Pernet, J. Mazzega, A. Grichine, C. Guilluy and M. E. Dolega. Molecular Biology of the Cell Vol. 32, No. 16 2021.

    Syndecan-4 forces integrins to cooperate. . Guilluy C. and Dolega M. Nature materials. 2020 Jun;19(6):587-588. doi: 10.1038/s41563-020-0689-5.

    Scavenger Receptor Cysteine-Rich Domains of Lysyl Oxidase-Like2 Regulate Endothelial ECM and Angiogenesis Through Non-Catalytic Scaffolding Mechanisms. . Umana-Diaz C., Pichol-Thievend C., Marchand MF., Atlas Y., Salza R., Malbouyres M., Barret A., Teillon J., Ardidie-Robouant C., Ruggiero F., Monnot C., Girard P., Guilluy C, Ricard-Blum S., Germain S. and Muller L. Matrix Biol. 2019, DOI: 10.1016/j.matbio.2019.11.003

    Nuclear envelope deformation controls cell cycle progression in response to mechanical force. . Aureille J., Buffière-Ribot V., Harvey B.E., Boyault C., Pernet L., Andersen T., Bacola G., Balland M., Fraboulet S., Van Landeghem L. and Guilluy C. EMBO Rep. 2019 Aug 1:e48084.

    RRAD mutation causes electrical and cytoskeletal defects in cardiomyocytes derived from a familial case of Brugada syndrome. . Belbachir N., Portero V., Al Sayed Z.R., Gourraud J.B., Dilasser F., Jesel L., Guo H., Wu H., Gaborit N, Guilluy C., Girardeau A., Bonnaud S., Simonet F., Karakachoff M., Pattier S., Scott C., Burel S., Marionneau C., Chariau C., Gaignerie A., David L., Genin E., Deleuze J.F., Dina C., Sauzeau V., Loirand G., Baró I., Schott J.J., Probst V., Wu J.C., Redon R., Charpentier F. and Le Scouarnec S. Eur Heart J. 2019 May 21.

    Analyzing Mechanotransduction Through the LINC Complex in Isolated Nuclei. . Belaadi N., Millon-Frémillon A., Aureille J. and Guilluy C. Methods Mol Biol. 2018;1840:73-80. doi: 10.1007/978-1-4939-8691-0_7.

    Analyzing Cell Surface Adhesion Remodeling in Response to Mechanical Tension Using Magnetic Beads. . Millon-Frémillon A., Aureille J. and Guilluy C. J Vis Exp. 2017 Mar 8;(121). doi: 10.3791/55330.

    Colorectal Cancer Cells Adhere to and Migrate Along the Neurons of the Enteric Nervous System. . Duchalais E., Guilluy C., Nedellec S., Touvron M., Bessard A., Touchefeu Y., Bossard C., Boudin H., Louarn G., Neunlist M. and Van Landeghem L. Cell Mol Gastroenterol Hepatol. 2017 Oct 14;5(1):31-49.

    Mechanotransduction via the nuclear envelope: a distant reflection of the cell surface. . Aureille J., Belaadi N. and Guilluy C. Curr Opin Cell Biol. 2017 Feb;44:59-67.

    Under Pressure: Mechanical Stress Management in the Nucleus. . Belaadi N., Aureille J. and Guilluy C. Cells. 2016 Jun 14;5(2). pii: E27. doi: 10.3390/cells5020027. Review.

    Focal adhesions, stress fibers and mechanical tension. . Belaadi N., Aureille J. and Guilluy C. Cells. 2016 Jun 14;5(2). pii: E27. doi: 10.3390/cells5020027. Review.

    Using magnets and magnetic beads to dissect signaling pathways activated by mechanical tension applied to cells. . Marjoram R.J., Guilluy C. and Burridge K. Methods. 2016 Feb 1;94:19-26. doi: 10.1016/j.ymeth.2015.09.025. Epub 2015 Sep 30.

    Nuclear mechanotransduction: forcing the nucleus to respond. . Guilluy C. and Burridge K. Nucleus. 2015;6(1):19-22. doi: 10.1080/19491034.2014.1001705. Review.

    Haemodynamic and extracellular matrix cues regulate the mechanical phenotype and stiffness of aortic endothelial cells. . Collins C, Osborne LD, Guilluy C, Chen Z, O'Brien ET 3rd, Reader JS, Burridge K, Superfine R, Tzima E. Nat Commun. 2014 Jun 11;5:3984.

    Vinculin phosphorylation differentially regulates mechanotransduction at cell-cell and cell-matrix adhesions . Bays JL, Peng X, Tolbert CE, Guilluy C, Angell AE, Pan Y, Superfine R, Burridge K, DeMali KA. J Cell Biol. 2014 Apr 28;205(2):251-63.

    Isolated nuclei adapt to force and reveal a mechanotransduction pathway within the nucleus. . Guilluy C, Osborne L, Van Landeghem L, Superfine R, Garcia-mata R and Burridge K. Nature Cell Biol. 2014 Mar 9. doi: 10.1038

    The RhoA guanine nucleotide exchange factor, LARG, mediates ICAM-1-dependent mechanotransduction in endothelial cells to stimulate transendothelial migration. . Lessey-Morillon E.C., Osborne L.D., Monaghan-Benson E., Guilluy C., O'Brien E.T., Superfine R. and Burridge K. J. Immunol. 2014 Apr 1;192(7):3390-8.

    Mechanically activated Fyn utilizes mTORC2 to regulate RhoA and adipogenesis in mesenchymal stem cells. . Thompson W.R., Guilluy C., Xie Z., Sen B., Brobst K.E., Yen S.S., Uzer G., Styner M., Case N., Burridge K. and Rubin J. Stem Cells. 2013 Nov;31(11):2528-37

    Localized tensional forces on PECAM-1 elicit a global mechanotransduction response via the integrin-RhoA pathway. . Collins C., Guilluy C., Welch C., O'Brien E.T., Hahn K., Superfine R., Burridge K. and Tzima E. Curr Biol. 2012 Nov 20;22(22):2087-94.

    From mechanical force to RhoA activation. . Lessey E.C., Guilluy C. and Burridge K. Biochemistry. 2012 Sep 25;51(38):7420-32. Review.

    Guilluy C, Dubash A and Garcia-Mata R Nature Protocols. 2011 Dec 1;6(12):2050-60. . Guilluy C, Dubash A and Garcia-Mata R Nature Protocols. 2011 Dec 1;6(12):2050-60.

    The Rho GEFs LARG and GEF-H1 regulate the mechanical response to force on integrins. . Guilluy C., Swaminathan V., Garcia-Mata R., O'Brien E.T., Superfine R. and Burridge K. Nature Cell Biol. 2011 Jun;13(6):722-7. Epub 2011 May 15.

    Rho protein crosstalk: another social network? . Guilluy C., Garcia-Mata R. and Burridge K. Trends Cell Biol. 2011 Dec;21(12):718-26. Review.

    Mechanically induced focal adhesion assembly amplifies anti-adipogenic pathways in mesenchymal stem cells. . Sen B., Guilluy C., Xie Z., Case N., Styner M., Thomas J., Oguz I., Rubin C., Burridge K. and Rubin J. Stem Cells. 2011 Nov;29(11):1829-36.

    Latent KSHV infection increases the vascular permeability of human endothelial cells. . Guilluy C., Zhang Z., Bhende P.M., Sharek L., Wang L., Burridge K. and Damania B. Blood. 2011 Aug 31.

    The Vinculin C-terminal Hairpin Mediates F-actin Bundle Formation, Focal Adhesion, and Cell Mechanical Properties. . Shen K., Tolbert C.E., Guilluy C., Swaminathan V.S., Berginski M.E., Burridge K., Superfine R. and Campbell S.L. J Biol Chem. 2011 Dec 30;286(52):45103-15.

    AMPK Alpha 1-Induced RhoA Phosphorylation Mediates Vasoprotective Effect of Estradiol. . Gayard M., Guilluy C., Rousselle A., Viollet B., Henrion D., Pacaud P., Loirand G. and Rolli-Derkinderen M. Arterioscler Thromb Vasc Biol. 2011 Aug 18

    The small GTPase RhoA localizes to the nucleus and is activated by Net1 and DNA damage signals. . Dubash A.D., Guilluy C., Srougi M.C., Boulter E., Burridge K. and García-Mata R. PLoS One. 2011 Feb 24;6(2):e17380.

    Increased Rho-kinase expression and activity and pulmonary endothelial dysfunction in smokers with normal lung function. . Duong-Quy S., Dao P., Hua-Huy T., Guilluy C., Pacaud P. and Dinh-Xuan A.T. Eur Respir J. 2011 Feb;37(2):349-55. Epub 2010 Jun 7.

    Regulation of Rho GTPase crosstalk, degradation and activity by RhoGDI1. . Boulter E., Garcia-Mata R., Guilluy C., Dubash A., Rossi G., Brennwald P.J. and Burridge K. Nature Cell Biol. 2010 May;12(5):477-83. Epub 2010 Apr 18.

    The Rho exchange factor Arhgef1 mediates the effects of angiotensin II on vascular tone and blood pressure. . Guilluy C., Brégeon J., Toumaniantz G., Rolli-Derkinderen M., Retailleau K., Loufrani L., Henrion D., Scalbert E., Bril A., Torres R.M., Offermanns S., Pacaud P., Loirand G. Nature Med. 2010 Feb;16(2):183-90. Epub 2010 Jan 24

    RhoA and Rho kinase activation in human pulmonary hypertension - Role of 5-HT signaling . Guilluy C., Eddahibi S., Agard C., Savale L., Humbert M., Fadel E., Adnot S., Pacaud P. and Loirand G Am J Respir Crit Care Med. 2009 Jun 15;179(12):1151-8.

    Ste20-related kinase SLK phosphorylates Ser 188 of RhoA to induce vasodilation in response to Angiotensin II type 2 receptor activation. . Guilluy C., Rolli-Derkinderen M., Loufrani L., Bourge A., Sabourin L., Henrion D., Loirand G. and Pacaud P. Circ Res. 2008 Apr 17

    Transglutaminase-dependent RhoA activation and depletion by serotonin in vascular smooth muscle cells. . Guilluy C., Rolli-Derkinderen M., Tharaux P.L., Melino G., Pacaud P. and Loirand G. J Biol Chem. 2007;282(5):2918-28.

    Hyaluronan induces vascular smooth muscle cell migration through RHAMM-mediated PI3K-dependent Rac activation. . Gouëffic Y., Guilluy C., Guérin P., Patra P., Pacaud P. and Loirand G. Cardiovasc Res. 2006 Nov 1;72(2):339-48. Epub 2006 Jul 29

    Regulation of Rho proteins by phosphorylation in the cadiovascular system. . Loirand G., Guilluy C. and Pacaud P. Trends Cardiovasc Med. 2006 Aug;16(6):199-204. Review.

    Inhibition of RhoA/Rho kinase pathway is involved in the beneficial effect of sildenafil on pulmonary hypertension. . Guilluy C, Sauzeau V, Rolli-Derkinderen M., Guérin P., Sagan C., Pacaud P. and Loirand G. Br J Pharmacol. 2005 Dec;146(7)