Staff
Christophe Guilluy, PhD (Group Leader) christophe.guilluy@inserm.fr
Selected publications
Aureille J, Buffière-Ribot V, Harvey BE, Boyault C, Pernet L, Andersen T, Bacola G, Balland M, Fraboulet S, Van Landeghem L, Guilluy C. Nuclear envelope deformation controls cell cycle progression in response to mechanical force. EMBO Rep. 2019
Guilluy C, Osborne L, Van Landeghem L, Superfine R, Garcia-mata R and Burridge K. Isolated nuclei adapt to force and reveal a mechanotransduction pathway within the nucleus. Nat Cell Biol. 2014 Mar 9. doi: 10.1038
Guilluy C, Swaminathan V, Garcia-Mata R, O’Brien ET, Superfine R, Burridge K. The Rho GEFs LARG and GEF-H1 regulate the mechanical response to force on integrins. Nat Cell Biol. 2011 Jun;13(6):722-7
Guilluy C, Burridge K. Nuclear mechanotransduction: forcing the nucleus to respond. Nucleus. 2015;6(1):19-22
Collins C, Guilluy C, Welch C, O’Brien ET, Hahn K, Superfine R, Burridge K, Tzima E. Localized tensional forces on PECAM-1 elicit a global mechanotransduction response via the integrin-RhoA pathway. Curr Biol. 2012 Nov 20;22(22):2087-94
Thompson WR, Guilluy C, Xie Z, Sen B, Brobst KE, Yen SS, Uzer G, Styner M, Case N, Burridge K, Rubin J.Mechanically activated Fyn utilizes mTORC2 to regulate RhoA and adipogenesis in mesenchymal stem cells. Stem Cells. 2013 Nov;31(11):2528-37
Complete list of publications
Sandrine Fraboulet, PhD (Associate Professsor) – sandrine.fraboulet@univ-grenoble-alpes.fr
Selected publications
V. Mercier, M.H. Laporte, O. Destaing, B. Blot, C.M. Bloin, K. Pernet-Gallay, C. Chatellard, Y. Saoudi, C. Albigez-Rizo, C. Lamaze, S. Fraboulet, A. Petiot, R. Sadoul. ALG-2 interacting protein-X (Alix) is essential for clathrin-independent endocytosis and signaling. Scientific Report. 2016 (6):26986
Chassefeyre, J. Martinez-Hernández, F. Bertaso, N. Bouquier, B. Blot, M. Laporte, S. Fraboulet, Y. Couté, A. Devoy, A. Isaacs, K. Pernet-Gallay, R. Sadoul, L. Fagni, Y. Goldberg. Regulation of post- synaptic function by the dementia-related ESCRT-III subunit chmp2b. Journal of Neuroscience. 2015 18; 35(7):3155-73. Erratum in: J Neurosci. 2015 May 20; 35(20): 8035-7.
Chivet, F. Hemming, K. Pernet-Gallay, S. Fraboulet, R. Sadoul. Emerging role of neuronal exosomes in the central nervous system. Front Physiol. 2012 3:145.
Briese, B. Esmaeili, S. Fraboulet, E.C. Burt, S. Christodoulou, P.R. Towers, K.E. Davies, D.B. Sattelle. Deletion of smn-1, the Caenorhabditis elegans orthologue of the spinal muscular atrophy gene, results in locomotor dysfunction and reduced lifespan. Hum Mol Genet. 2009 18(1):97-104.
A.L. Mahul-Mellier, F. Strappazzon, A. Petiot, C. Chatellard-Causse, S. Torch, B. Blot, K. Freeman, L. Kuhn, J. Garin, J.M. Verna, S. Fraboulet, R.Sadoul. Alix and ALG-2 are involved in TNF-R1 induced cell death. J. Biol. Chem. 2008 283(50):34954-65.
Complete list of publications
Monika Elzbieta Dolega, PhD (Research Associate) monika.dolega@univ-grenoble-alpes.fr
Selected publications
Dolega ME, Delarue M, Ingremeau F, Prost J, Delon A, Cappello G. Cell-like pressure sensors reveal increase of mechanical stress towards the core of multicellular spheroids under compression. Nat. Commun. 2017 Jan 27;8:14056. doi: 10.1038/ncomms14056.
Dolega ME, Abeille F, Picollet-D’hahan N, Gidrol X. Controlled 3D culture in Matrigel microbeads to analyze clonal acinar development. Biomaterials. 2015 Jun;52:347-57. doi: 10.1016/j.biomaterials.2015.02.042. Epub 2015 Mar 3.
Dolega ME, Wagh J, Gerbaud S, Kermarrec F, Alcaraz JP, Martin DK, Gidrol X, Picollet-D’hahan. Facile bench-top fabrication of enclosed circular microchannels provides 3D confined structure for growth of prostate epithelial cells. PLoS One. 2014 Jun 19;9(6):e99416. doi: 10.1371/journal.pone.0099416. eCollection 2014.
Complete list of publications
Lydia Pernet, PhD (Engineer) lydia.pernet@univ-grenoble-alpes.fr
Responsabilities in the lab:
– Experiments in biochemistry, molecular and cellular biology
– Cell culture line maintenance
– Development of ATACseq experiments
Professionnal training:
– Molecular biology -> qPCR
– Health & Safety à Prevention Assistant and workplace first-aider
Other tasks:
– In charge of the culture room maintenance
– Students supervision
– Purchasing manager
Pernet L, Faure V, Gilquin B, Dufour-Guérin S, Khochbin S, Vourc’h C. HDAC6-ubiquitin interaction controls the duration of HSF1 activation after heat shock. Mol. Biol. Cell. 2014, doi: 10.1091/mbc.E14-06-1032.
Marvin Brun-Cosme-bruny, PhD (Research Associate) marvin.brun-cosme-bruny@univ-grenoble-alpes.fr
Publications : – Brun-Cosme-Bruny, M., Bertin, E., Coasne, B., Peyla, P., & Rafaï, S. (2019). Effective diffusivity of microswimmers in a crowded environment. The Journal of chemical physics, 150(10), 104901.– Brun-Cosme-Bruny, M., Förtsch, A., Zimmermann, W., Bertin, E., Peyla, P., & Rafaï, S. (2020). Deflection of phototactic microswimmers through obstacle arrays. arXiv preprint arXiv:2005.05677.– Brun-Cosme-Bruny, M., Borne, V., Faure, S., Maury, B., Peyla, P., & Rafai, S. (2019). Extreme congestion of microswimmers at a bottleneck constriction. arXiv preprint arXiv:1911.10681.
Investigating vimentin intermediate filaments’ response to mechanical stimulii within a cell monolayer
Background :
-Biophysics, Statistical physics & Hydrodynamics
-Diffusion process and crowd motion in Active matter
-Microfluidics, Cells on chips
